Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66777265, compound

HRID 2090917Notes

Reaction equation

HRID 2090917 reaction equation
[CH:1]1([CH:7]([C:9]2[C:10]([O:25][CH3:26])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=3)[CH:13]=2)O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:27][C:28]1[CH:33]=[CH:32][C:31]([C:34]([N:36]([CH3:44])[CH2:37][CH2:38][C:39]([O:41]CC)=[O:40])=[O:35])=[CH:30][CH:29]=1>>[CH:1]1([CH:7]([NH:27][C:28]2[CH:29]=[CH:30][C:31]([C:34]([N:36]([CH3:44])[CH2:37][CH2:38][C:39]([OH:41])=[O:40])=[O:35])=[CH:32][CH:33]=2)[C:9]2[C:10]([O:25][CH3:26])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=3)[CH:13]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 66777596HCID 66777596, compound

Product 1

HCID 66777265HCID 66777265, compoundYield 12%

Procedure

Using cyclohexyl{3-methoxy-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl}methanol (0.75 g) synthesized in Example 62(2) and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (0.50 g) synthesized in Example 2(2) and in the same manner as in Example 1(7), the title object compound (0.13 g, 12%) was obtained as a white solid.

Sources & evidence

ORD record
ord-cc6fbcbe51f34be1bc55f45331d8214e
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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