Ethyl 3-(4-aminobenzamido)propanoate → HCID 66777960, compound

HRID 2090918Notes

Reaction equation

HRID 2090918 reaction equation
[CH:1]1([CH:7]([C:9]2[C:10]([O:25][CH:26]([CH3:28])[CH3:27])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=3)[CH:13]=2)O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]([NH:38][CH2:39][CH2:40][C:41]([O:43]CC)=[O:42])=[O:37])=[CH:32][CH:31]=1>>[CH:1]1([CH:7]([NH:29][C:30]2[CH:31]=[CH:32][C:33]([C:36]([NH:38][CH2:39][CH2:40][C:41]([OH:43])=[O:42])=[O:37])=[CH:34][CH:35]=2)[C:9]2[C:10]([O:25][CH:26]([CH3:27])[CH3:28])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][C:21]([F:22])([F:23])[F:24])=[CH:16][CH:15]=3)[CH:13]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66777290HCID 66777290, compound

Product 1

HCID 66777960HCID 66777960, compoundYield 37.2%

Procedure

Using cyclohexyl{3-(1-methylethoxy)-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl}methanol (0.20 g) synthesized above and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (0.12 g) synthesized in Example 1(2) and in the same manner as in Example 1(7), the title object compound (0.11 g, 36%) was obtained as a white solid.

Sources & evidence

ORD record
ord-7c1d2f8e72cb440a965f59648800aeb4
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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