Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66779532, compound

HRID 2090919Notes

Reaction equation

HRID 2090919 reaction equation
[CH:1]1([CH:7]([C:9]2[C:10]([O:25][CH:26]([CH3:28])[CH3:27])=[N:11][N:12]([C:14]3[CH:19]=[CH:18][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:16][CH:15]=3)[CH:13]=2)O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:29][C:30]1[CH:35]=[CH:34][C:33]([C:36]([N:38]([CH3:46])[CH2:39][CH2:40][C:41]([O:43]CC)=[O:42])=[O:37])=[CH:32][CH:31]=1>>[CH:1]1([CH:7]([NH:29][C:30]2[CH:31]=[CH:32][C:33]([C:36]([N:38]([CH3:46])[CH2:39][CH2:40][C:41]([OH:43])=[O:42])=[O:37])=[CH:34][CH:35]=2)[C:9]2[C:10]([O:25][CH:26]([CH3:27])[CH3:28])=[N:11][N:12]([C:14]3[CH:15]=[CH:16][C:17]([O:20][C:21]([F:24])([F:23])[F:22])=[CH:18][CH:19]=3)[CH:13]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 66777290HCID 66777290, compound

Product 1

HCID 66779532HCID 66779532, compoundYield 36.4%

Procedure

Using cyclohexyl{3-(1-methylethoxy)-1-[4-(trifluoromethoxy)phenyl]-1H-pyrazol-4-yl}methanol (0.20 g) synthesized in Example 64(2) and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (0.13 g) synthesized in Example 2(2) and in the same manner as in Example 1(7), the title object compound (0.11 g, 36%) was obtained as a white solid.

Sources & evidence

ORD record
ord-8d797d6d19204282b1245070b090a033
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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