Ethyl 3-(methylamino)propanoate → HCID 66777968, compound

HRID 2090979Notes

Reaction equation

HRID 2090979 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH:10]([NH:17][C:18]2[CH:26]=[CH:25][C:21]([C:22](O)=[O:23])=[CH:20][CH:19]=2)[CH:11]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12]2)=[CH:2]1.[CH3:27][NH:28][CH2:29][CH2:30][C:31]([O:33]CC)=[O:32]>>[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[C:3]([CH:10]([NH:17][C:18]2[CH:26]=[CH:25][C:21]([C:22]([N:28]([CH3:27])[CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[O:23])=[CH:20][CH:19]=2)[CH:11]2[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16]2)=[CH:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 66777972HCID 66777972, compound

Product 1

HCID 66777968HCID 66777968, compoundYield 71.4%

Procedure

Using 4-{[1-benzothiophen-3-yl(cyclohexyl)methyl]amino}benzoic acid (250 mg) synthesized in Example A1(3) and ethyl 3-(methylamino)propanoate (108 mg) and in the same manner as in Example A1(4), the title object compound (220 mg, 71%) was obtained as a white solid.

Sources & evidence

ORD record
ord-b74bac40981d4bd6add8b37fbe27614a
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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