Ethyl 3-(methylamino)propanoate → HCID 66778242, compound

HRID 2090985Notes

Reaction equation

HRID 2090985 reaction equation
[CH:1]1([CH:7]([NH:18][C:19]2[CH:27]=[CH:26][C:22]([C:23](O)=[O:24])=[CH:21][CH:20]=2)[C:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[S:10][C:9]=2[CH3:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:28][NH:29][CH2:30][CH2:31][C:32]([O:34]CC)=[O:33]>>[CH:1]1([CH:7]([NH:18][C:19]2[CH:20]=[CH:21][C:22]([C:23]([N:29]([CH3:28])[CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:24])=[CH:26][CH:27]=2)[C:8]2[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=3[S:10][C:9]=2[CH3:17])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 66777772HCID 66777772, compound

Product 1

HCID 66778242HCID 66778242, compoundYield 85%

Procedure

Using 4-{[cyclohexyl(2-methyl-1-benzothiophen-3-yl)methyl]amino}benzoic acid (300 mg) synthesized in Example A8(4) and ethyl 3-(methylamino)propanoate (124 mg) and in the same manner as in Example A1(4), the title object compound (312 mg, 85%) was obtained as a white solid.

Sources & evidence

ORD record
ord-0a0dd7ab8e554d9e88e02ab38bb93543
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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