Water → HCID 36995608, compound

Participants

Reaction Steps

To a solution (40 mL) of methyl 5-(trifluoromethyl)-1-benzothiophene-2-carboxylate (2.00 g) in tetrahydrofuran was added lithium aluminum hydride (292 mg) at 0° C., and the mixture was stirred for 1 hr. Water (300 μL) was added to quench the reaction, 1N aqueous sodium hydroxide solution (300 μL) was added, and the mixture was stirred at room temperature for 3 hr. The resulting insoluble material was filtered off, and the filtrate was concentrated under reduced pressure to give a white solid. To a solution of the obtained solid in tetrahydrofuran (40 mL) was added active manganese dioxide (9.00 g), and the mixture was stirred overnight at room temperature. Manganese dioxide was filtered off, and the filtrate was concentrated under reduced pressure to give the title object compound (1.15 g, 65%) as a brown solid.

Provenance & Evidence