Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66778473, compound

HRID 2090993Notes

Reaction equation

HRID 2090993 reaction equation
Cl[CH:2]([CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[N:4]=1.[NH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]([N:33]([CH3:41])[CH2:34][CH2:35][C:36]([O:38]CC)=[O:37])=[O:32])=[CH:27][CH:26]=1>>[CH:18]1([CH:2]([NH:24][C:25]2[CH:26]=[CH:27][C:28]([C:31]([N:33]([CH3:41])[CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[O:32])=[CH:29][CH:30]=2)[C:3]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]([C:12]3[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=3)[N:4]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 66778954HCID 66778954, compound

Product 1

HCID 66778473HCID 66778473, compoundYield 12.4%

Procedure

Using 3-[chloro(cyclohexyl)methyl]-1-phenyl-1H-indazole (397 mg) synthesized in Example A14(4) and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (305 mg) synthesized in Example 2(2) and in the same manner as in Example A7(3), the title object compound (76.9 mg, 12%) was obtained as a pale-yellow solid.

Sources & evidence

ORD record
ord-c92ee8902d58416e842cd74fb9d7e366
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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