Thionyl Chloride → HCID 66777149, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of cyclohexyl(3-methyl-1-benzofuran-2-yl)methanol (843 mg) synthesized above and toluene (20 mL) was added thionyl chloride (256 μL), and the mixture was stirred at room temperature for 2.5 hr and at 50° C. for 1.5 hr. Saturated aqueous sodium hydrogen carbonate solution was added to quench the reaction, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give the title object compound (862 mg, 95%) as a yellow oil.

Provenance & Evidence