Ethyl 3-(4-aminobenzamido)propanoate → HCID 66778639, compound

HRID 2090997Notes

Reaction equation

HRID 2090997 reaction equation
Cl[CH:2]([CH:13]1[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1)[C:3]1[O:4][C:5]2[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=2[C:7]=1[CH3:8].[NH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]([NH:28][CH2:29][CH2:30][C:31]([O:33]CC)=[O:32])=[O:27])=[CH:22][CH:21]=1>>[CH:13]1([CH:2]([NH:19][C:20]2[CH:21]=[CH:22][C:23]([C:26]([NH:28][CH2:29][CH2:30][C:31]([OH:33])=[O:32])=[O:27])=[CH:24][CH:25]=2)[C:3]2[O:4][C:5]3[CH:12]=[CH:11][CH:10]=[CH:9][C:6]=3[C:7]=2[CH3:8])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14]1

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66777149HCID 66777149, compound

Product 1

HCID 66778639HCID 66778639, compoundYield 37.4%

Procedure

Using 2-[chloro(cyclohexyl)methyl]-3-methyl-1-benzofuran (433 mg) synthesized in Example A16(3) and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (390 mg) synthesized in Example 1(2) and in the same manner as, in Example A7(3), the title object compound (268 mg, 37%) was obtained as a white solid.

Sources & evidence

ORD record
ord-ccad85997f5a45a6922b39bfc6a8f556
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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