Ethyl 3-(4-aminobenzamido)propanoate → HCID 66777324, compound

HRID 2090999Notes

Reaction equation

HRID 2090999 reaction equation
Cl[CH:2]([CH:18]1[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1)[C:3]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]([CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)[N:4]=1.[NH2:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]([NH:33][CH2:34][CH2:35][C:36]([O:38]CC)=[O:37])=[O:32])=[CH:27][CH:26]=1>>[CH:18]1([CH:2]([NH:24][C:25]2[CH:26]=[CH:27][C:28]([C:31]([NH:33][CH2:34][CH2:35][C:36]([OH:38])=[O:37])=[O:32])=[CH:29][CH:30]=2)[C:3]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]([CH:12]3[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)[N:4]=2)[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66777943HCID 66777943, compound

Product 1

HCID 66777324HCID 66777324, compoundYield 72.6%

Procedure

Using 3-[chloro(cyclohexyl)methyl]-1-cyclohexyl-1H-indazole (400 mg) synthesized in Example A18(4) and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (286 mg) synthesized in Example 1(2) and in the same manner as in Example A7(3), the title object compound (441 mg, 72%) was obtained as a white solid.

Sources & evidence

ORD record
ord-159277d8e83a45f69f1f32fc8dfc4e39
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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