Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66777716, compound

HRID 2091007Notes

Reaction equation

HRID 2091007 reaction equation
Cl[CH:2]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:3]1[O:4][C:5]2[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:6]=2[CH:7]=1.[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([N:29]([CH3:37])[CH2:30][CH2:31][C:32]([O:34]CC)=[O:33])=[O:28])=[CH:23][CH:22]=1>>[CH:14]1([CH:2]([NH:20][C:21]2[CH:22]=[CH:23][C:24]([C:27]([N:29]([CH3:37])[CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:28])=[CH:25][CH:26]=2)[C:3]2[O:4][C:5]3[CH:11]=[CH:10][C:9]([O:12][CH3:13])=[CH:8][C:6]=3[CH:7]=2)[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 66778151HCID 66778151, compound

Product 1

HCID 66777716HCID 66777716, compoundYield 14.5%

Procedure

Using 2-[chloro(cyclohexyl)methyl]-5-methoxy-1-benzofuran (361 mg) synthesized in Example A22(3) and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (325 mg) synthesized in Example 2(2) and in the same manner as in Example A22(4), the title object compound (87.0 mg, 14%) was obtained as a white solid.

Sources & evidence

ORD record
ord-392c9b6e968c411ea3811d9979461a7a
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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