Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66778367, compound

HRID 2091011Notes

Reaction equation

HRID 2091011 reaction equation
Cl[CH:2]([CH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1)[C:3]1[O:4][C:5]2[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:6]=2[C:7]=1[CH3:8].[NH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]([N:30]([CH3:38])[CH2:31][CH2:32][C:33]([O:35]CC)=[O:34])=[O:29])=[CH:24][CH:23]=1>>[CH:15]1([CH:2]([NH:21][C:22]2[CH:23]=[CH:24][C:25]([C:28]([N:30]([CH3:38])[CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[O:29])=[CH:26][CH:27]=2)[C:3]2[O:4][C:5]3[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[CH:9][C:6]=3[C:7]=2[CH3:8])[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 66777945HCID 66777945, compound

Product 1

HCID 66778367HCID 66778367, compound

Procedure

Using 2-[chloro(cyclohexyl)methyl]-5-methoxy-3-methyl-1-benzofuran (395 mg) synthesized above and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (338 mg) synthesized in Example 2(2) and in the same manner as in Example A22(4), the title object compound (305 mg, 47%) was obtained as a white solid.

Sources & evidence

ORD record
ord-e55787988d7d4129a3eed7f1347e1617
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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