Ethyl 3-(methylamino)propanoate → HCID 66778456, compound

HRID 2091014Notes

Reaction equation

HRID 2091014 reaction equation
[CH:1]1([CH:7]([NH:19][C:20]2[CH:28]=[CH:27][C:23]([C:24](O)=[O:25])=[CH:22][CH:21]=2)[C:8]2[O:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:29][NH:30][CH2:31][CH2:32][C:33]([O:35]CC)=[O:34]>>[CH:1]1([CH:7]([NH:19][C:20]2[CH:28]=[CH:27][C:23]([C:24]([N:30]([CH3:29])[CH2:31][CH2:32][C:33]([OH:35])=[O:34])=[O:25])=[CH:22][CH:21]=2)[C:8]2[O:9][C:10]3[CH:16]=[C:15]([O:17][CH3:18])[CH:14]=[CH:13][C:11]=3[CH:12]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 66778513HCID 66778513, compound

Product 1

HCID 66778456HCID 66778456, compound

Procedure

Using 4-{[cyclohexyl(6-methoxy-1-benzofuran-2-yl)methyl]amino}benzoic acid (300 mg) synthesized above and ethyl 3-(methylamino)propanoate (125 mg) and in the same manner as in Example A1(4), the title object compound (201 mg, 55%) was obtained as a white solid.

Sources & evidence

ORD record
ord-aad1371c809c446488ceff17f707de46
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

Loading…