Ethyl 3-(4-aminobenzamido)propanoate → HCID 66778191, compound

HRID 2091015Notes

Reaction equation

HRID 2091015 reaction equation
Cl[CH:2]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:3]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[O:5][C:4]=1[CH2:12][CH3:13].[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([NH:29][CH2:30][CH2:31][C:32]([O:34]CC)=[O:33])=[O:28])=[CH:23][CH:22]=1>>[CH:14]1([CH:2]([NH:20][C:21]2[CH:22]=[CH:23][C:24]([C:27]([NH:29][CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:28])=[CH:25][CH:26]=2)[C:3]2[C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=3[O:5][C:4]=2[CH2:12][CH3:13])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66777754HCID 66777754, compound

Product 1

HCID 66778191HCID 66778191, compoundYield 77.3%

Procedure

Using 3-[chloro(cyclohexyl)methyl]-2-ethyl-1-benzofuran (300 mg) synthesized in Example A26(2) and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (255 mg) synthesized in Example 1(2) and in the same manner as in Example A22(4), the title object compound (374 mg, 77%) was obtained as a pale-brown solid.

Sources & evidence

ORD record
ord-476cfca7a61e43b888e88dbfe1738ebd
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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