Ethyl 3-(methylamino)propanoate → HCID 66777594, compound

HRID 2091021Notes

Reaction equation

HRID 2091021 reaction equation
[CH3:1][CH:2]([CH3:25])[CH2:3][CH:4]([NH:15][C:16]1[CH:24]=[CH:23][C:19]([C:20](O)=[O:21])=[CH:18][CH:17]=1)[C:5]1[S:6][C:7]2[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=2[C:9]=1[CH3:10].[CH3:26][NH:27][CH2:28][CH2:29][C:30]([O:32]CC)=[O:31]>>[CH3:26][N:27]([C:20]([C:19]1[CH:18]=[CH:17][C:16]([NH:15][CH:4]([C:5]2[S:6][C:7]3[CH:14]=[CH:13][CH:12]=[CH:11][C:8]=3[C:9]=2[CH3:10])[CH2:3][CH:2]([CH3:25])[CH3:1])=[CH:24][CH:23]=1)=[O:21])[CH2:28][CH2:29][C:30]([OH:32])=[O:31]

Participants

3

Reactant 2

HCID 541480Ethyl 3-(methylamino)propanoateHCID 66777989HCID 66777989, compound

Product 1

HCID 66777594HCID 66777594, compound

Procedure

Using 4-{[3-methyl-1-(3-methyl-1-benzothiophen-2-yl)butyl]amino}benzoic acid (300 mg) synthesized above and ethyl 3-(methylamino)propanoate (134 mg) and in the same manner as in Example A1(4), the title object compound (218 mg, 59%) was obtained as a white solid.

Sources & evidence

ORD record
ord-74121de081b24a92a6e8bf6e4f83d713
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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