Ethyl 3-(4-aminobenzamido)propanoate → HCID 66778144, compound

HRID 2091022Notes

Reaction equation

HRID 2091022 reaction equation
Cl[CH:2]([C:7]1[O:8][C:9]2[CH:17]=[CH:16][CH:15]=[CH:14][C:10]=2[C:11]=1[CH2:12][CH3:13])[CH2:3][CH:4]([CH3:6])[CH3:5].[NH2:18][C:19]1[CH:24]=[CH:23][C:22]([C:25]([NH:27][CH2:28][CH2:29][C:30]([O:32]CC)=[O:31])=[O:26])=[CH:21][CH:20]=1>>[CH2:12]([C:11]1[C:10]2[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=2[O:8][C:7]=1[CH:2]([NH:18][C:19]1[CH:20]=[CH:21][C:22]([C:25]([NH:27][CH2:28][CH2:29][C:30]([OH:32])=[O:31])=[O:26])=[CH:23][CH:24]=1)[CH2:3][CH:4]([CH3:6])[CH3:5])[CH3:13]

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66777313HCID 66777313, compound

Product 1

HCID 66778144HCID 66778144, compoundYield 32%

Procedure

Using 2-(1-chloro-3-methylbutyl)-3-ethyl-1-benzofuran (300 mg) synthesized in Example A31(4) and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (283 mg) synthesized in Example 1(2) and in the same manner as in Example A22(4), the title object compound (162 mg, 32%) was obtained as a pale-brown solid.

Sources & evidence

ORD record
ord-5878d43ad4ac43e3bfc12735f42c5722
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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