Hydrochloric Acid → 5-fluoro-N-methoxy-N,3-dimethyl-1-benzofuran-2-carboxamide

Participants

Reaction Conditions

Reaction Steps

To a mixture of 1-(5-fluoro-2-hydroxyphenyl)ethanone (10.0 g), 2-chloro-N-methoxy-N-methylacetamide (9.82 g), sodium iodide (19.5 g) and N,N-dimethylformamide (200 mL) was added potassium carbonate (18.0 g), and the mixture was stirred at 80° C. overnight. 1N Hydrochloric acid was added to quench the reaction, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give a brown solid. To a solution (200 mL) of the obtained solid in N,N-dimethylformamide was added 1,8-diazabicyclo[5.4.0]undec-7-ene (9.71 mL), and the mixture was stirred at 120° C. for 4 hr. 1N Hydrochloric acid was added to quench the reaction, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:3, volume ratio) to give the title object compound (4.37 g, 28%) as a brown oil.

Provenance & Evidence