Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate → HCID 66778068, compound

HRID 2091026Notes

Reaction equation

HRID 2091026 reaction equation
Cl[CH:2]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:3]1[O:4][C:5]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=2[C:7]=1[CH3:8].[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([N:29]([CH3:37])[CH2:30][CH2:31][C:32]([O:34]CC)=[O:33])=[O:28])=[CH:23][CH:22]=1>>[CH:14]1([CH:2]([NH:20][C:21]2[CH:22]=[CH:23][C:24]([C:27]([N:29]([CH3:37])[CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:28])=[CH:25][CH:26]=2)[C:3]2[O:4][C:5]3[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=3[C:7]=2[CH3:8])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 46941342Ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoateHCID 66777694HCID 66777694, compound

Product 1

HCID 66778068HCID 66778068, compound

Procedure

Using 2-[chloro(cyclohexyl)methyl]-5-fluoro-3-methyl-1-benzofuran (400 mg) synthesized above and ethyl 3-{[(4-aminophenyl)carbonyl](methyl)amino}propanoate (355 mg) synthesized in Example 2(2) and in the same manner as in Example A22(4), the title object compound (303 mg, 46%) was obtained as a pale-yellow solid.

Sources & evidence

ORD record
ord-a419b288e6d44e12ad97d0acc30b4cac
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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