Ethyl 3-(4-aminobenzamido)propanoate → HCID 66778913, compound

HRID 2091027Notes

Reaction equation

HRID 2091027 reaction equation
Cl[CH:2]([CH:14]1[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1)[C:3]1[O:4][C:5]2[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=2[C:7]=1[CH3:8].[NH2:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([NH:29][CH2:30][CH2:31][C:32]([O:34]CC)=[O:33])=[O:28])=[CH:23][CH:22]=1>>[CH:14]1([CH:2]([NH:20][C:21]2[CH:22]=[CH:23][C:24]([C:27]([NH:29][CH2:30][CH2:31][C:32]([OH:34])=[O:33])=[O:28])=[CH:25][CH:26]=2)[C:3]2[O:4][C:5]3[CH:12]=[CH:11][C:10]([F:13])=[CH:9][C:6]=3[C:7]=2[CH3:8])[CH2:19][CH2:18][CH2:17][CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 12469762Ethyl 3-(4-aminobenzamido)propanoateHCID 66777694HCID 66777694, compound

Product 1

HCID 66778913HCID 66778913, compoundYield 50%

Procedure

Using 2-[chloro(cyclohexyl)methyl]-5-fluoro-3-methyl-1-benzofuran (400 mg) synthesized in Example A37(3) and ethyl 3-{[(4-aminophenyl)carbonyl]amino}propanoate (336 mg) synthesized in Example 1(2) and in the same manner as in Example A22(4), the title object compound (321 mg, 50%) was obtained as a pale-brown solid.

Sources & evidence

ORD record
ord-28ff0c7c424548fe83875b7d9f4a3c3b
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

Loading…