Ammonium Chloride → HCID 66778779, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 6-(trifluoromethyl)imidazo[1,2-a]pyridine-2-carbaldehyde (2.1 g) synthesized above in tetrahydrofuran (40 mL) was added dropwise cyclohexylmagnesium bromide (1M tetrahydrofuran solution, 15 mL) at 0° C. After stirring at 0° C. for 1 hr, aqueous ammonium chloride solution was added. The mixture was extracted with ethyl acetate, and the solvent was evaporated under reduced pressure. The precipitate was washed with ethanol-diisopropyl ether to give the title object compound (0.9 g, 30%) as a colorless solid.

Provenance & Evidence