Hydrochloric Acid → HCID 66777111, compound

Participants

Reaction Steps

To a mixture of 4-{[cyclohexyl(5-methoxy-3-methyl-1-benzofuran-2-yl)methyl]amino}benzoic acid (745 mg) synthesized above, ethyl 3-(methylamino)propanoate (298 mg), 1-hydroxybenzotriazole monohydrate (348 mg), triethylamine (633 μL) and N,N-dimethylformamide (10 mL) was added 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (435 mg), and the mixture was stirred at room temperature for overnight then at 50° C. for 3 hr. 1N Hydrochloric acid was added to quench the reaction, and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous sodium hydrogen carbonate solution and saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (55% ethyl acetate/hexane) to give the title object compound (801 mg, 84%) as a pale-brown solid.

Provenance & Evidence