Azobisisobutyronitrile → HCID 66778012, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (150 mL) of methyl 5-fluoro-3-methyl-1-benzofuran-2-carboxylate (15.4 g) synthesized above in acetonitrile were added N-bromosuccinimide (19.8 g) and 2,2′-azobis(isobutyronitrile) (1.21 g), and the mixture was stirred under argon atmosphere at 50° C. for 2.5 days. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (20-30% ethyl acetate/hexane) to give a white solid. The obtained solid was washed with hexane to give the title object compound (15.1 g, 71%) as a white solid.

Provenance & Evidence