Hydrochloric Acid → HCID 66777791, compound

Participants

Reaction Steps

To a solution (50 mL) of methyl 3-(bromomethyl)-5-fluoro-1-benzofuran-2-carboxylate (5.87 g) synthesized above in methanol was added 28% solution (8.33 mL) of sodium methoxide in methanol, and the mixture was stirred with heating under reflux for 3 hr. 1N Hydrochloric acid was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (50% ethyl acetate/hexane) to give the title object compound (3.04 g, 63%) as a white solid.

Provenance & Evidence