Cyclohexyl methyl ketone → 2-Bromo-1-cyclohexylethanone

Participants

Reaction Steps

To a solution (50 mL) of 1-cyclohexylethanone (25.0 g) in methanol was added bromine (10.1 mL) at 0° C., and the mixture was stirred at room temperature for 30 min. Saturated sodium sulfite aqueous solution was added to quench the reaction, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (0-10% ethyl acetate/hexane) to give the title object compound (25.8 g, 63%) as a colorless oil.

Provenance & Evidence