Ethanol → HCID 44227315, compound

Participants

Reaction Steps

To a mixture of ethyl 3-[{[4-({1-[5-(cyclopropylmethoxy)-3-methyl-1-benzofuran-2-yl]-2-methylpropyl}amino)phenyl]carbonyl}(methyl)amino]propanoate (667 mg) obtained in Example A75(4) in tetrahydrofuran (3 mL) and ethanol (3 mL) was added 1N aqueous sodium hydroxide solution (2.6 mL), and the mixture was stirred at room temperature for 30 min. The reaction mixture was concentrated under reduced pressure, the residue was dissolved in water (4 mL), and 1N hydrochloric acid (2.6 mL) was added at 0° C. The mixture was stirred at 0° C. for 30 min, and the resulting precipitate was collected by filtration to give the title compound (509 mg, 81%) as a colorless amorphous form.

Provenance & Evidence