Hydrochloric Acid → HCID 66777748, compound

Participants

Reaction Steps

Cyclohexyl[5-(2-methoxyethoxy)-3-methyl-1-benzofuran-2-yl]methanone (10.3 g) synthesized in the above-mentioned (2) was dissolved in a mixed solvent of tetrahydrofuran (180 mL) and methanol (20 mL). The reaction mixture was ice-cooled, and sodium borohydride (90%, 2.7 g) was added, and the reaction mixture was stirred at room temperature for 2 hr. The reaction mixture was ice-cooled again, water (10 mL) and 1N hydrochloric acid (100 mL) were carefully added, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give a crude product (10.3 g) of the title object compound as a pale-yellow oil.

Provenance & Evidence