Sodium Hydroxide → HCID 66777638, compound

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Reaction Conditions

Reaction Steps

Ethyl 3-[{[4-({cyclohexyl[5-(2-methoxyethoxy)-3-methyl-1-benzofuran-2-yl]methyl}amino)phenyl]carbonyl}(methyl)amino]propanoate (5.4 g) synthesized in the above-mentioned (4) was dissolved in ethanol (150 mL), 1N aqueous sodium hydroxide solution (15 mL) was added at room temperature, and the mixture was stirred at 50° C. for 0.5 hr. Ethanol was evaporated under reduced pressure, 1N hydrochloric acid (20 mL) was added to the residue, and the mixture was extracted with diethyl ether. The extract was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (ethyl acetate:hexane=1:1, volume ratio) to give the title object compound (3.0 g, 59%) as a white solid.

Provenance & Evidence