Potassium Carbonate → HCID 66777037, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (500 mL) of 1-[5-(benzyloxy)-2-hydroxyphenyl]ethanone (29.5 g) synthesized in the above-mentioned (1) in N,N-dimethylformamide were added potassium carbonate (41.4 g) and 2-bromo-1-cyclohexylethanone (25.0 g) synthesized in Example A51(1) at room temperature, and the mixture was stirred at 60° C. for 15 hr. The reaction mixture was allowed to cool to room temperature, filtered through celite. Water was added to the filtrate, and the mixture was extracted with diethyl ether. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give a solid. The obtained solid was washed with ethanol-isopropyl ether to give the title object compound (18.0 g, 43%) as a pale-yellow solid.

Provenance & Evidence