Sodium Hydroxide → HCID 66777645, compound

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Reaction Steps

Ethyl 3-[{[4-({cyclohexyl[3-methyl-5-(tetrahydro-2H-pyran-4-yloxy)-1-benzofuran-2-yl]methyl}amino)phenyl]carbonyl}(methyl)amino]propanoate (0.6 g) synthesized in the above-mentioned (6) was dissolved in ethanol (20 mL), 1N aqueous sodium hydroxide solution (3 mL) was added at room temperature, and the mixture was stirred at room temperature for 12 hr. Ethanol was evaporated under reduced pressure, 1N hydrochloric acid (3 mL) was added to the residue, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was recrystallized from acetone to give the title object compound (0.5 g, 77%) as colorless crystals.

Provenance & Evidence