Sodium Hydroxide → HCID 66777645, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 3-[{[4-({cyclohexyl[3-methyl-5-(tetrahydro-2H-pyran-4-yloxy)-1-benzofuran-2-yl]methyl}amino)phenyl]carbonyl}(methyl)amino]propanoate (1.8 g) optically resolved in the above-mentioned (1) was dissolved in ethanol (20 mL), 1N aqueous sodium hydroxide solution (5 mL) was added at room temperature, and the mixture was stirred at 50° C. for 0.5 hr. Ethanol was evaporated under reduced pressure, 1N hydrochloric acid (5 mL) was added to the residue, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was recrystallized from acetone to give the title object compound (1.5 g, 88%, 99.9% ee) as colorless crystals.

Provenance & Evidence