Phenol → HCID 66779142, compound

Participants

Reaction Steps

To a mixture of 2-bromo-1-(3-methyl-1-benzofuran-2-yl)ethanone (1.00 g), phenol (446 mg) and N,N-dimethylformamide (20 mL) was added potassium carbonate (655 mg), and the mixture was stirred overnight at room temperature. Saturated aqueous ammonium chloride solution was added to quench the reaction, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (10% ethyl acetate/hexane) to give the title object compound (697 mg, 66%) as a yellow solid.

Provenance & Evidence