Bromine → HCID 86662735, compound

HRID 2091169Notes

Reaction equation

HRID 2091169 reaction equation
[CH3:1][O:2][N:3]([CH3:17])[C:4]([C:6]1[O:7][C:8]2[CH:14]=[CH:13][C:12]([O:15][CH3:16])=[CH:11][C:9]=2[CH:10]=1)=[O:5].[Br:18]Br>C(O)(=O)C>[Br:18][C:10]1[C:9]2[CH:11]=[C:12]([O:15][CH3:16])[CH:13]=[CH:14][C:8]=2[O:7][C:6]=1[C:4]([N:3]([O:2][CH3:1])[CH3:17])=[O:5]

Participants

4

Reactant 2

HCID 24408BromineHCID 86672902HCID 86672902, compound

Product 1

HCID 86662735HCID 86662735, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

To a solution (100 mL) of N,5-dimethoxy-N-methyl-1-benzofuran-2-carboxamide (9.24 g) synthesized above in acetic acid was added dropwise bromine (2.21 mL), and the mixture was stirred overnight at room temperature. The resulting precipitate was collected by filtration and washed with diisopropyl ether to give the title object compound (9.48 g, 77%) as an orange solid.

Workup

  1. filtrationThe resulting precipitate was collected by filtration
  2. washwashed with diisopropyl ether

Sources & evidence

ORD record
ord-855ea570262a4e1ab19ec4da85fddfac
Source dataset
uspto-grants-2013_05
Patent number
US08436043B2

Reaction notes

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