Thionyl Chloride → HCID 66777958, compound

Participants

Reaction Conditions

Reaction Steps

To a solution (20 mL) of (3-bromo-5-methoxy-1-benzofuran-2-yl)(cyclohexyl)methanol (1.82 g) synthesized above in toluene was added thionyl chloride (469 μL) and the mixture was stirred at 100° C. for 1.5 hr. The reaction mixture was poured into ice-cooled saturated aqueous sodium hydrogen carbonate solution, and the mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give the title object compound (1.73 g, 90%) as a yellow solid.

Provenance & Evidence