Dimethyl Sulfoxide → HCID 66777025, compound

Participants

Reaction Steps

To a mixture of dimethyl sulfoxide (831 mL) and tetrahydrofuran (20 mL) was added trifluoroacetic acid anhydride (1.63 mL) at −78° C., and the mixture was stirred for 30 min, and a solution (20 mL) of (3-bromo-5-methoxy-1-benzofuran-2-yl)(cyclohexyl)methanol (2.03 g) synthesized in Example A102(4) in tetrahydrofuran was added. The reaction mixture was stirred under argon atmosphere at −78° C. for 1 hr, triethylamine (3.33 mL) was added, and the mixture was stirred at room temperature for 1 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (15% ethyl acetate/hexane) to give the title object compound (1.52 g, 75%) as a white solid.

Provenance & Evidence