Lithium Hydroxide → HCID 66777340, compound

Participants

Reaction Steps

To a mixture of ethyl 3-[{[4-({[5-(acetylamino)-3-methyl-1-benzofuran-2-yl](cyclohexyl)methyl}amino)phenyl]carbonyl}(methyl)amino]-propanoate (366 mg) synthesized above, tetrahydrofuran (5 mL) and ethanol (5 mL) was added 1N lithium hydroxide aqueous solution (1.00 mL), and the mixture was stirred at room temperature for 1 hr. 1N Lithium hydroxide aqueous solution (1.00 mL) was additionally added, and the mixture was stirred at room temperature for 1 hr, and concentrated under reduced pressure. The residue was dissolved in water (10 mL), and 1N hydrochloric acid (2.00 mL) was added at 0° C. The resulting precipitate was collected by filtration to give the title object compound (292 mg, 84%) as a white solid.

Provenance & Evidence