Lithium Hydroxide → HCID 68627902, compound

Participants

Reaction Steps

To a mixture of ethyl 3-[({4-[(cyclohexyl{5-[(ethylcarbamoyl)amino]-3-methyl-1-benzofuran-2-yl}methyl)amino]phenyl}carbonyl)(methyl)amino]propanoate (304 mg) synthesized above, tetrahydrofuran (5 mL) and ethanol (5 mL) was added 1N lithium hydroxide aqueous solution (2.00 mL), and the mixture was stirred at room temperature for 2 hr, and concentrated under reduced pressure. The residue was dissolved in water (10 mL), and 1N hydrochloric acid (2.00 mL) was added at 0° C. The resulting precipitate was collected by filtration to give the title object compound (258 mg, 89%) as a white solid.

Provenance & Evidence