Lithium Hydroxide → HCID 86662749, compound

Participants

Reaction Steps

To a mixture of ethyl 3-{[(4-{[(5-chloro-3-methylfuro[3,2-b]pyridin-2-yl)(cyclohexyl)methyl]amino}phenyl)carbonyl](methyl)amino}-propanoate (332 mg) synthesized above, tetrahydrofuran (5 mL) and ethanol (5 mL) was added 1N lithium hydroxide aqueous solution (3.00 mL), and the mixture was stirred overnight at room temperature, and concentrated under reduced pressure. The residue was dissolved in water (10 mL), and 1N hydrochloric acid (3.00 mL) was added at 0° C. The resulting precipitate was collected by filtration to give the title object compound (278 mg, 89%) as a pale-yellow solid.

Provenance & Evidence