Benzenesulfonyl chloride → HCID 66778378, compound

Participants

Reaction Steps

To a solution (10 mL) of ethyl 3-{[(4-{[(5-amino-3-methyl-1-benzofuran-2-yl)(cyclohexyl)methyl]amino}phenyl)carbonyl](methyl)amino}-propanoate (254 mg) synthesized in Example A110(5) in N,N-dimethylacetamide was added benzenesulfonyl chloride (99 μL), and the mixture was stirred overnight at room temperature. Saturated aqueous ammonium chloride solution was added to quench the reaction, and the reaction mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (30-70% ethyl acetate/hexane) to give the title object compound (312 mg, 96%) as a colorless oil.

Provenance & Evidence