Tetrahydrofuran → HCID 66777357, compound

Participants

Reaction Steps

To a mixture of ethyl 3-[({4-[(cyclohexyl{3-methyl-5-[(phenylsulfonyl)amino]-1-benzofuran-2-yl}methyl)amino]phenyl}carbonyl)(methyl)amino]propanoate (312 mg) synthesized above, tetrahydrofuran (5 mL) and ethanol (5 mL) was added 1N aqueous sodium hydroxide solution (2.00 mL), and the mixture was stirred at room temperature for 5 hr, and concentrated under reduced pressure. The residue was dissolved in water (10 mL), and 1N hydrochloric acid (2.00 mL) was added at 0° C. The resulting precipitate was collected by filtration to give the title object compound (240 mg, 80%) as a white solid.

Provenance & Evidence