Sodium Bicarbonate → HCID 66777774, compound

Participants

Reaction Steps

To a mixture of methyl 5-fluoro-3-[(2-methoxyethoxy)methyl]-1-benzofuran-2-carboxylate (1.54 g) synthesized above, calcium chloride (1.21 g), ethanol (15 mL) and tetrahydrofuran (15 mL) was added sodium borohydride (825 mg) at 0° C., and the mixture was stirred at room temperature for 3 hr. Saturated aqueous sodium hydrogen carbonate solution was added to quench the reaction, and the reaction mixture was extracted with ethyl acetate. The extract was washed with saturated brine, dried over magnesium sulfate, and concentrated under reduced pressure to give the title object compound (1.34 g, 97%) as a pale-yellow oil.

Provenance & Evidence