HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → HCID 66777830, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | HCID 66778745 | HCID 66778745 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 66777830 | HCID 66777830 | 89% |
Reaction Steps
Ethyl 3-({[4-({1-[5-(benzyloxy)-3-methyl-1-benzofuran-2-yl]-2-methylpropyl}amino)phenyl]carbonyl}amino)propanoate (0.43 g) synthesized in the above-mentioned (1) was dissolved in ethanol (10 mL), 1N aqueous sodium hydroxide solution (2.0 mL) was added to the solution at room temperature, and the mixture was stirred at room temperature for 0.5 hr. Ethanol was evaporated under reduced pressure, and 1N hydrochloric acid (2.0 mL) was added to the residue. The precipitate was washed with water to give the title object compound (0.36 g, 89%) as a colorless solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08436043B2 |
| Source dataset | uspto-grants-2013_05 |
| ORD ID | ord-e9913bd409634f30b2a9b2240a59e2f9 |
| Source note | uspto-grants-2013_05 |