Cesium carbonate → HCID 66778355, compound

Participants

Reaction Steps

To a solution (15 mL) of (5-bromo-3-methyl-1-benzofuran-2-yl)(cyclohexyl)methanone (0.75 g) synthesized in Example A174(1) in toluene were added thiomorpholine (0.72 g), cesium carbonate (2.3 g), tris(dibenzylideneacetone)dipalladium (0) (0.16 g) and 9,9-dimethyl-4,5-bis(diphenylphosphino)xanthene (0.2 g), and the mixture was heated under reflux under argon atmosphere for 18 hr. The reaction mixture was cooled to room temperature and filtered through celite, water was added to the residue, and the mixture was extracted with ethyl acetate. The extract was concentrated to give a crude product (0.83 g, quantitative) of the title object compound as a yellow oil.

Provenance & Evidence