Sodium Hydroxide → HCID 66779124, compound

Participants

Reaction Steps

Ethyl 3-{[(4-{[cyclopentyl(5-fluoro-3-methyl-1-benzofuran-2-yl)methyl]amino}phenyl)carbonyl]amino}propanoate (363 mg) synthesized in Example A189 was dissolved in ethanol (1.5 mL) and tetrahydrofuran (1.5 mL), 1N aqueous sodium hydroxide solution (1.5 mL) was added to the solution, and the mixture was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure, water (4 mL) was added to the mixture, and the mixture was neutralized with 1N hydrochloric acid under ice-cooling, and the mixture was stirred for 30 min. The resulting precipitate was collected by filtration, and dried to give the title compound (283 mg, 83%) as a colorless solid.

Provenance & Evidence