Thionyl Chloride → HCID 66777786, compound

Participants

Reaction Steps

To a solution of [5-(benzyloxy)-3-methyl-1-benzofuran-2-yl](cyclohexyl)methanol (25.17 g) synthesized above in tetrahydrofuran (250 mL) was added thionyl chloride (9.44 mL) at room temperature. The reaction mixture was stirred at room temperature for 1 hr. To the reaction mixture was added aqueous sodium hydrogen carbonate solution cooled to 0° C., and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to give the title compound (25.39 g, 96%) as a yellow solid.

Provenance & Evidence