Sodium Hydroxide → HCID 66779140, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 3-{[(4-{[{5-[(5-cyanopyridin-2-yl)oxy]-3-methyl-1-benzofuran-2-yl}(cyclohexyl)methyl]amino}phenyl)carbonyl](methyl)amino}-propanoate (300 mg) obtained in Example A201 was dissolved in tetrahydrofuran (4.0 mL), and 1N aqueous sodium hydroxide solution (1.1 mL) was added to the solution, and the mixture was stirred at 50° C. for 1 hr. The solvent was evaporated under reduced pressure, water (4 mL) was added to the residue, and the mixture was neutralized with 1N hydrochloric acid (1.1 mL) under ice-cooling and stirred at 0° C. for 30 min. The resulting precipitate was collected by filtration, and dried to give the title compound (271 mg, 87%) as a colorless amorphous form.

Provenance & Evidence