反应详情

1-[5-(Benzyloxy)-3-methyl-1-benzofuran-2-yl]-2-methylpropan-1-one (4.0 g) synthesized in Example A85(1) was dissolved in ethanol (80 mL), and palladium carbon-ethylenediamine complex (400 mg) was added to the solution at room temperature. The reaction mixture was stirred under hydrogen atmosphere (1 atm) at room temperature for 9.5 hr. The catalyst was filtered off, and the filtrate was concentrated under reduced pressure to give the title compound (2.82 g, 100%) as a colorless solid.

1. additionpalladium carbon-ethylenediamine complex (400 mg) was added to the solution at room temperature
2. filtrationThe catalyst was filtered off
3. concentrationthe filtrate was concentrated under reduced pressure