Sodium Hydroxide → HCID 66778972, compound

Participants

Reaction Steps

Ethyl 3-(methyl{[4-({2-methyl-1-[3-methyl-5-(tetrahydro-2H-thiopyran-4-yloxy)-1-benzofuran-2-yl]propyl}amino)phenyl]carbonyl}amino)propanoate (485 mg) synthesized in Example A203 was dissolved in ethanol (2.0 mL) and tetrahydrofuran (2.0 mL), and 1N aqueous sodium hydroxide solution (1.96 mL) was added to the solution, and the mixture was stirred at room temperature for 0.5 hr. The solvent was evaporated under reduced pressure, water (4 mL) was added to the residue, and the mixture was neutralized with 1N hydrochloric acid (1.96 mL) under ice-cooling, and stirred for 30 min. The resulting precipitate was collected by filtration, and dried to give the title compound (421 mg, 91%) as a colorless amorphous form.

Provenance & Evidence