Sodium Hydroxide → HCID 66777933, compound

Participants

Reaction Conditions

Reaction Steps

Ethyl 3-{methyl[(4-{[2-methyl-1-(3-methyl-5-{[5-(trifluoromethyl)pyridin-2-yl]oxy}-1-benzofuran-2-yl)propyl]amino}phenyl)carbonyl]amino}propanoate (425 mg) synthesized in Example A205 was dissolved in tetrahydrofuran (4.0 mL), 1N aqueous sodium hydroxide solution (1.4 mL) was added to the solution, and the mixture was stirred at 50° C. for 1.5 hr. The solvent was evaporated under reduced pressure, water (4 mL) was added to the residue, and the mixture was neutralized with 1N hydrochloric acid (1.4 mL) under ice-cooling and stirred for 20 min. The resulting precipitate was collected by filtration, and dried to give the title compound (378 mg, 94%) as a colorless amorphous form.

Provenance & Evidence