HCID 66777585, compound → HCID 66778521, compound

Participants

Reaction Steps

Ethyl 3-{[(4-{[cyclopentyl(5,7-difluoro-3-methyl-1-benzofuran-2-yl)methyl]amino}phenyl)carbonyl](methyl)amino}propanoate (240 mg) synthesized in Example A207 was dissolved in ethanol (1.0 mL)-tetrahydrofuran (1.0 mL), 1N aqueous sodium hydroxide solution (0.96 mL) was added to the solution, and the mixture was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure, water (4 mL) was added to the residue, and the mixture was neutralized with 1N hydrochloric acid (0.96 mL) under ice-cooling, and stirred for 15 min. The resulting precipitate was collected by filtration, and dried to give the title compound (185 mg, 82%) as a colorless amorphous form.

Provenance & Evidence