Water → HCID 66777218, compound

Participants

Reaction Conditions

Reaction Steps

Cyclohexyl[3-methyl-5-(tetrahydrofuran-2-ylmethoxy)-1-benzofuran-2-yl]methanone (260 mg) synthesized above was dissolved in methanol (0.5 mL)-tetrahydrofuran (2.5 mL), and sodium tetrahydroborate (90%) (64 mg) was added to the solution at 0° C. The reaction mixture was stirred at 0° C. for 2.5 hr. Water was added to the reaction mixture, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, and dried over anhydrous magnesium sulfate. After filtration, the filtrate was concentrated to give the title compound (235 mg, 90%) as a colorless oil.

Provenance & Evidence